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The Washington Post:
Patrick V. Murphy, 91, a reform-minded law enforcement official who was nationally known for trying to defuse tensions between police and inner-city residents, and who shaped and supervised the District's efforts to deal with the historic rioting of 1968, died Dec. 16 at a hospital in Wilmington, N.C.
He had a heart attack, his son Gerard Murphy told the Associated Press.
Read the whole story: The Washington Post
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updated 3:16 p.m. ET Dec. 17, 2011
LONDON - Chelsea missed a chance to put pressure on the two Manchester clubs at the top of the Premier League on Saturday, yielding a goal with two minutes left in a 1-1 draw at relegation-threatened Wigan.
Chelsea looked on course for a fourth straight Premier League victory when Daniel Sturridge scored his eighth goal of the season in the 59th minute. But Wigan dominated the second half and Jordi Gomez tapped in from close range after a mistake by Chelsea goalkeeper Petr Cech.
The result left Chelsea with 32 points from 16 matches, four behind second-place Manchester United and six behind longtime leader City.
Defending champion United could take first place for the first time since mid-October if it wins at Queens Park Rangers on Sunday and Manchester City loses to visiting Arsenal. Sunderland is at fourth-place Tottenham and Liverpool is at Aston Villa in Sunday's other matches.
The draw left Wigan in the relegation zone with Blackburn and Bolton, which remained anchored to the bottom of the league after a 2-0 loss at Fulham
Two weeks after becoming the most prolific American scorer in England's top division, Clint Dempsey scored his 38th Premier League goal to get Fulham rolling. He scored his fifth league goal this season and eighth overall with a 32nd-minute header from Bryan Ruiz's cross. Costa Rica forward Ruiz chipped over goalkeeper Jussi Jaaskelainen to make it 2-0 two minutes later.
Last-place Bolton has only nine points from 16 games. That's one fewer than Blackburn, which lost 2-1 to visiting West Bromwich Albion. Peter Odemwingie scored West Brom's winning goal with a minute left.
Wolverhampton is one place and one point above the relegation zone after giving up two second-half goals in a 2-1 loss against Stoke. Stoke is three points behind Newcastle, which spent three months in the top four but is now without a win in five matches after drawing 0-0 with visiting Swansea.
In the League Championship, American defender Daniel Potts made his debut for West Ham in a 1-0 home draw against Barnsley. A member of the U.S. Under-20 team, Potts is captain of the Hammers' Under-18 team and signed a 2 1-2-year professional contract on Friday. He overcame leukemia two years ago.
___
BERLIN (AP) ? Defending champion Borussia Dortmund will go into the Bundesliga's four-week winter break three points behind leader Bayern Munich after beating last-place Freiburg 4-1.
Robert Lewandowski scored the first of his two goals in the seventh minute. Jan Rosenthal tied it in the 34th but Ilkay Guendogan restored the visitors' lead in the 44th, before Kevin Grosskreutz added another goal in the 59th and then crossed for Lewandowski to complete the scoring in the 70th.
On Friday, Bayern clinched the unofficial title of "winter champion" with a 3-0 win over Cologne on Friday.
Raul Gonzalez scored a hat-trick to help Schalke rout Werder Bremen 5-0, with Kyriakos Papadopoulos and Klaas Jan Huntelaar also scoring to complete a miserable evening for Werder goalkeeper Tim Wiese on his 30th birthday. Schalke and Dortmund have 34 points.
Relegation-threatened Nuremberg ended Bayer Leverkusen's six-game unbeaten run in the league with a 3-0 win, Wolfsburg beat Stuttgart 1-0, Hamburger SV drew 1-1 with Augsburg and Roman Hubnik scored in injury time to rescue a 1-1 draw for Hertha Berlin at Hoffenheim.
___
BARCELONA, Spain (AP) ? Getafe rallied past Mallorca 2-1 on two goals by Abdel Barrada for its first road victory of the Spanish league season.
Barrada offset Ivan Ramis' opening goal when his shot deflected off a defender before landing in the back of the net in the 28th minute. In the 44th, he tapped Nicolas "Miku" Fedor's cross into an empty net.
Sergio Garcia's 84th-minute winner gave Espanyol a 2-1 victory at Sporting Gijon.
___
MILAN (AP) ? Chievo got back to winning ways in the Italian league with goals from Cyril Thereau and Gennaro Sardo in a 2-0 victory over Cagliari.
Thereau gave Chievo the lead in the 35th minute and Sardo struck shortly before the 60th, giving Chievo its first win in four matches.
Chievo moves into the top half of the standings ahead of the rest of the weekend games and is seven points off the relegation zone. Cagliari is one point behind.
___
GLASGOW, Scotland (AP) ? Carlos Bocanegra scored to help first-place Rangers defeat visiting Inverness 2-1 in the Scottish Premier League.
Bocanegra, one of three Americans starting for the defending champions, put Rangers ahead in the 55th minute with a close-range shot. Andrew Shinnie evened the scores 12 minutes later. Shinnie had a goal ruled out for offside before substitute Kyle Lafferty scored in the 87th minute.
Americans Maurice Edu and Alejandro Bedoya also started for Rangers.
Rangers have 48 points to 41 for Celtic, which plays at St. Johnstone on Sunday.
___
ATHENS, Greece (AP) ? Sebastian Leto scored once in each half and set up a goal by Jean-Alain Boumsong to lead Panathinaikos to a 3-1 victory over visiting Asteras in the Greek league.
Fernando Usero scored a late goal for Asteras.
Panathinaikos overtook AEK for second place and is a point behind defending champion Olympiakos, which has played one more game. Olympiakos hosts Giannena and AEK plays at Atromitos on Sunday.
Ergotelis won 1-0 at Levadiakos and Xanthi beat visiting Panionios by the same score.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More newsEuro Roundup: Chelsea missed a chance to put pressure on the two Manchester clubs at the top of the Premier League on Saturday, yielding a goal with two minutes left in a 1-1 draw at relegation-threatened Wigan.
Mike Stobe / Getty ImagesSource: http://nbcsports.msnbc.com/id/45708628/ns/sports-soccer/
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TOKYO ? Declaring Japan has turned a corner in the battle to stabilize its tsunami-damaged nuclear plant, Prime Minister Yoshihiko Noda announced Friday the facility has achieved a stable state of "cold shutdown," a crucial step toward lifting evacuation orders and closing the plant.
Noda's announcement was intended to reassure the nation that significant progress has been made in the nine months since the March 11 tsunami sent three reactors at the Fukushima Dai-ichi plant into meltdowns in the worst nuclear crisis since Chernobyl in 1986.
But the plant 140 miles (230 kilometers) northeast of Tokyo remains vulnerable to problems, its surroundings are contaminated by radiation and closing the plant safely will take 30 or more years.
"The reactors at the Fukushima Dai-ichi nuclear power plant have reached a state of cold shutdown," Noda said. "Now that we have achieved stability in the reactors, a major concern for the nation has been resolved."
Noda said he hopes conditions will improve quickly so that the people who have been displaced by the crisis can return home "even a day sooner."
"There are many issues that remain," Noda said. "Our battle is not over."
The government's official endorsement of the claim by Tokyo Electric Power Co. that the reactors have reached cold shutdown status is a necessary step toward revising evacuation zones around the plant and focusing efforts from simply stabilizing the facility to actually starting the arduous process of shutting it down.
But Noda acknowledged the assessment has some important caveats.
The government says Fukushima Dai-ichi has reached cold shutdown "conditions"_ a cautious phrasing reflecting the fact that TEPCO cannot measure temperatures of melted fuel in the damaged reactors in the same way as with normally functioning ones.
Even so, the announcement marks the end of the second phase of the government's lengthy roadmap to completely decommission the plant.
Officials can now start discussing whether to allow some evacuees to return to less-contaminated areas ? although a 12-mile (20-kilometer) zone around the plant is expected to remain off limits for years to come. The crisis displaced some 100,000 people.
Noda said the government will step up decontamination efforts and will ready 1 trillion yen ($12.8 billion) for urgently needed projects next year. He also said 30,000 workers will be trained.
A cold shutdown normally means a nuclear reactor's coolant system is at atmospheric pressure and its reactor core is at a temperature below 212 degrees Fahrenheit (100 degrees Celsius), making it impossible for a chain reaction to take place.
According to TEPCO, temperature gauges inside the Fukushima reactors show the pressure vessel is at around 70 C (158 F). The government also says the amount of radiation now being released around the plant is at or below 1 millisievert per year ? equivalent to the annual legal exposure limit for ordinary citizens before the crisis began.
Akira Yamaguchi, a nuclear physicist at Osaka University, said that the government's definition of cold shutdown is disputable.
"But what's most important right now is that there aren't any massive radiation leaks any more," he said.
Putting longer-term issues aside, he warned that much of the backup equipment installed at the plant since the crisis began is makeshift and may break down. He said winter cold could test their strength.
___
Associated Press writer Eric Talmadge contributed to this report.
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ScienceDaily (Dec. 16, 2011) ? Will a drug used to treat childhood acute lymphoblastic leukemia and other pediatric cancers cause heart problems later in life?
UB associate professor of pharmaceutical sciences, Javier G. Blanco, PhD, who sees his work as a bridge between research and clinical practice, has focused recent efforts on trying to answer this question.
Blanco and colleagues' recent study in the Journal of Clinical Oncology looked for the underlying genetic answers to why some childhood cancer survivors who were treated with anthracylines -- powerful antibiotics like Adriamycin and Daunomycin -- developed cardiomyopathy, such as congestive heart failure, later in life.
"Anthracyclines are effective drugs used to treat a variety of pediatric cancers, they are also used to treat breast cancer and other malignancies in adults," Blanco says. "After cancer, survivors can develop cardiac toxicity anywhere from one year to more than 15 years after the initial chemotherapy with anthracyclines. The window separating the effectiveness of these drugs from their toxicity is narrow. The dosage has to be precise to achieve a therapeutic effect without toxicity."
Blanco explains that the key to individualizing any drug treatment comes down to understanding the way an individual is genetically coded to respond to the drug once it enters the body, and then adjusting the dose accordingly.
Working closely with Smita Bhatia, MD, MPH, chair of the Department of Population Sciences at City of Hope National Medical Center in California and senior author of the study, Blanco and a team of researchers decided to look at how the drug was broken down by enzymes encoded by specific genes.
The study, which began seven years ago, compared DNA genotypes of 170 childhood cancer survivors diagnosed with anthracycline-related cardiomyopathy to a control group of 317 survivors without heart disease.
Using the candidate gene approach, Blanco and his team were able to identify a tiny gene variant related to the risk of cardiotoxicity.
"We pinpointed the genetic difference or polymorphism that makes an enzyme work faster or slower in patients," said Blanco, "slower is better."
They zeroed-in on carbonyl reductases (CBR1 and CBR3) -- two enzymes that break down anthracyclines into cardiotoxic alcohol metabolites. Blanco notes that in mouse models, higher levels of CBRs or faster enzymes dictate higher levels of these metabolites -- and more cardio toxicity.
The research showed that the risk of cardiomyopathy was significantly increased among individuals with two copies of the "G" version of the CBR3 polymorphism when exposed to low-to-moderate doses of anthracycline.
Blanco says that while the results of the study validated the findings of an earlier study in a totally independent cohort of cancer survivors, further study is required.
"We have to be careful," says Blanco. "So far, we are showing an association, not yet causation. Our next step will be to conduct a prospective study -- where we don't study individuals who were exposed to anthracyclines in the past but follow them in real time as they are receiving the drug and after."
What does this mean for children who are taking or have taken anthracyclines?
"If we stop using anthracyclines we will not be able to cure up to 90 percent of the children who suffer from acute lymphoblastic leukemia." Blanco says. "Parents must continue to have their children's health monitored long after the cancer is cured to identify cardiac problems if they develop."
Blanco's research is primarily funded by the National Institute of General Medical Sciences (NIGMS), the Lance Armstrong Foundation and the Leukemia and Lymphoma Society, among many others.
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Source: http://www.sciencedaily.com/releases/2011/12/111216175244.htm
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Over the twenty years of its existence, New York City's annual Spanish Cinema Now series has come to serve as the American showcase for vibrant, thought-provoking films in Spanish cinema. A new generation of comic filmmakers first met American audiences with our longest-running series at Film Society of Lincoln Center: Alex de la Iglesias, Santiago Segura, Ventura Pons, and Daniel Sanchez Arevalo, among others. Female directors, such as Iciar Bolain, Gracia Querejta, Helena Taberna and Isabel Coixet, have been prominently featured, as have the new approaches to classic genres as seen in the films of Nacho Vigalondo, Jaume Balaguer, and Javier Gutierrez. Spanish Cinema Now has also provided the occasion for retrospective homages to artists ranging from directors Carlos Saura, Victor Erice and Manuel Gutierrez Aragon to actors such as Javier Bardem and Javier Camera.
Back in the Eighties, before I was working at Lincoln Center, I would come to New York from Chicago (where I was living) to attend Spanish film week organized by the Spanish Ministry of Culture. My good friend, Carmelo Romero, head of international film promotion for the Ministry in those years, organized these shows, which took place in various cinemas around town that had been rented for the occasion. After I got my Lincoln Center job, I told Carmelo that as soon as our new cinema--a place that was to be called the Walter Reade Theater--would be up and running, I'd be delighted to host the Spanish film week. We made a date to have our first collaboration in the fall of 1989, just after the Walter Reade was scheduled to open (September 1989).
New York building projects being what they are, the Walter Reade didn't open in fact until December 1991, but every time I saw Carmelo I'd renew my promise. Finally, after some negotiation, we agreed on October 1992, to be the launch of our first series. Dramatically titled "Out of the Ashes," this first Lincoln Center Spanish show proved a great success, introducing audiences to films such as Bogas Luna's JAMON JAMON (as well as to Penelope Cruz and Javier Bardem in that film), and Carlos Saura's marvelous dance film SEVILLANAS. Encouraged, we decided we'd repeat our collaboration the next year, only we'd move the series into early December, and it's remained there ever since.
Together, Spanish cinema and the Film Society have taken quite a journey. When the series began in 1992, Spanish cinema was at a particularly low point: production was down to 40 films a year (down from highs of almost 200 in the Seventies), and Spanish cinema could not even claim ten percent of its domestic box office. The older, established generation of filmmakers had perhaps lost touch with Spanish audiences, especially younger audiences; raised in the shadow of Franco, this generation of filmmakers specialized in a somewhat closed, allegorical cinema, used as it was to hiding messages and themes from the censors. Yet the new generation was all about openness, about putting it out there, and there was no greater symbol of this than the one Spanish filmmaker who continued to enjoy growing international success in these years: Pedro Almod?var, who once went so far as to claim that he made films "as if Franco had never existed."
In the twenty years since the founding of Spanish Cinema Now (Film Society of Lincoln Center's longest-running series), Spanish Cinema has continued to struggle to both maintain its domestic box office as well as to establish expanded markets around the world, yet there can be little doubt of its importance today--both as a source for talented directors and actors, as well as one of the most aesthetically provocative cinema anywhere.
We're proud to be a small part of this cinematic renaissance, and are grateful to Spanish cinema for all the pleasure it continues to give our audiences.
Film Society of Lincoln Center's Spanish Cinema Now series is currently celebrating 20 years with an exciting lineup of films, shorts, documentaries and a tribute to the late great director Luis Garc?a Berlanga, all currently playing at Walter Reade Theater until December 22. Visit www.filmlinc.com for schedule, tickets and information.
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Source: http://www.huffingtonpost.com/richard-pena/cinematic-renaissance-in-_b_1146946.html
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MEXICO CITY ? Mexican authorities said Tuesday that an alleged founder of the Zetas drug cartel had an arsenal of 169 guns when he was captured Monday, and may have been linked to the abduction of nine Mexican marines.
Navy spokesman Jose Luis Vergara said suspect Raul Lucio Hernandez Lechuga oversaw Zeta operations around the Gulf coast state of Veracruz, where nine marines disappeared earlier this year.
Vergara said a suspect was killed and a marine wounded in a firefight that erupted during Hernandez Lechuga's capture Monday in the Veracruz state city of Cordoba. The bust was the result of a yearlong intelligence operation, Vergara said.
Marines found 133 rifles, five grenade launchers, 29 grenades and 36 pistols at the scene of the raid near a highway. Marines also found bulletproof vests with the letter "Z", the zetas symbol, on the front.
Vergara said Hernandez Lechuga was one of Mexico's 37 most-wanted drug traffickers, and that with his arrest, 22 of those 37 have either been killed or detained.
The Zetas have been linked to some of the apparent abductions of Mexican marines, but Vergara didn't say what specific evidence authorities had of Hernandez Lechuga's involvement in the cases.
The apparent abductions of Mexican navy personnel have been shrouded in mystery, with the navy previously acknowledging that three marines and a navy cadet were abducted by suspected drug cartel gunmen in August in Veracruz, the state's largest city.
Later that month, the navy said it had found four bodies in a pit on the outskirts of Veracruz city, and that the remains might be those of the missing marines, but it never publicly confirmed that was the case.
At a Tuesday press conference where Hernandez Lechuga and four alleged associates were paraded before the media, Vergara said a total of nine marines had disappeared, but didn't say whether any of them had been found.
Mexican drug cartels have kidnapped and killed military personnel before, but such incidents remain relatively rare.
Hernandez Lechuga was the leader of the Zetas in about 10 states, including Veracruz. The federal government had offered a reward of 15 million pesos, or about $1.2 million, for information leading to his arrest. Vergara said the U.S. Drug Enforcement Administration was also offering a $1 million reward for Hernandez Lechuga, known by the nickname "Lucky."
The Zetas organization was formed by a small group of elite soldiers based in Tamaulipas state, across the border from Texas, who deserted to work for the Gulf drug cartel in the 1990s.
The Zetas split from their former allies in the Gulf cartel last year, setting off bloody fights throughout Mexico as they sought to expand south.
In Veracruz, the Zetas are currently believed to be locked in a bloody turf battle with groups allied with the Sinaloa cartel.
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